Lithiated porous silicon nanowires stimulate periodontal regeneration

0582132 - ÚŽFG 2025 RIV US eng J - Článek v odborném periodiku
Kaasalainen, M. - Zhang, R. - Vashisth, P. - Birjandi, A. A. - S'Ari, M. - Martella, D. A. - Isaacs, M. - Makila, E. - Wang, C. - Moldenhauer, E. - Clarke, P. - Pinna, A. - Zhang, X. - Mustfa, S. A. - Caprettini, V. - Morrell, A. P. - Gentleman, E. - Brauer, D. S. - Addison, O. - Zhang, X. - Bergholt, M. - Al-Jamal, K. - Volponi, A. A. - Salonen, J. - Hondow, N. - Sharpe, Paul - Chiappini, C.
Lithiated porous silicon nanowires stimulate periodontal regeneration.
Nature Communications. Roč. 15, č. 1 (2024), č. článku 487. E-ISSN 2041-1723
Grant CEP: GA ČR(CZ) GA21-21409S
Institucionální podpora: RVO:67985904
Klíčová slova: signaling pathway * lithium * activation * differentiation * anode * glass * nanoparticles * bioactivity
Obor OECD: Cell biology
Impakt faktor: 16.6, rok: 2022
Způsob publikování: Open access
https://www.nature.com/articles/s41467-023-44581-5

Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/beta-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/beta-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect.
Trvalý link: https://hdl.handle.net/11104/0352853