A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression.

0581691 - ÚOCHB 2025 RIV NL eng J - Článek v odborném periodiku
Chrudinová, M. - Kirk, N. S. - Chuard, A. - Venugopal, H. - Zhang, F. - Lubos, Marta - Gelfanov, V. - Páníková, Terezie - Žáková, Lenka - Cutone, J. - Mojares, M. - DiMarchi, R. - Jiráček, Jiří - Altindis, E.
A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression.
Molecular Metabolism. Roč. 80, February (2024), s. 101863. ISSN 2212-8778. E-ISSN 2212-8778
Grant CEP: GA MŠMT(CZ) LX22NPO5104
Institucionální podpora: RVO:61388963
Klíčová slova: viral insulin/IGF-1 like peptides (VILPs) * IGF-1 * insulin * IGF1 receptor * IGF1 receptor inhibition * biased signaling * iridoviridae
Impakt faktor: 8.1, rok: 2022
Způsob publikování: Open access
https://doi.org/10.1016/j.molmet.2023.101863

OBJECTIVE: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study aims to characterize the impact of Mandarin fish ranavirus (MFRV) and Lymphocystis disease virus-Sa (LCDV-Sa) VILPs on the insulin/IGF system for the first time.
Trvalý link: https://hdl.handle.net/11104/0349880