Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes

0580591 - BC 2024 RIV US eng J - Článek v odborném periodiku
Padilla-Mejia, N.E. - Field, Mark Christian
Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes.
FEBS Letters. Roč. 597, č. 20 (2023), s. 2501-2518. ISSN 0014-5793. E-ISSN 1873-3468
GRANT EU: Wellcome Trust(GB) 204697/Z/16/Z
Institucionální podpora: RVO:60077344
Klíčová slova: pore complex components * molecular architecture * integrative structure * a-type * nucleoporin * protein * lamina * chromatin * form * identification * evolutionary diversity * nuclear lamina * nuclear pore complex * nucleus * trypanosoma
Obor OECD: Cell biology
Impakt faktor: 3.5, rok: 2022
Způsob publikování: Open access
https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14747

One of the remarkable features of eukaryotes is the nucleus, delimited by the nuclear envelope (NE), a complex structure and home to the nuclear lamina and nuclear pore complex (NPC). For decades, these structures were believed to be mainly architectural elements and, in the case of the NPC, simply facilitating nucleocytoplasmic trafficking. More recently, the critical roles of the lamina, NPC and other NE constituents in genome organisation, maintaining chromosomal domains and regulating gene expression have been recognised. Importantly, mutations in genes encoding lamina and NPC components lead to pathogenesis in humans, while pathogenic protozoa disrupt the progression of normal development and expression of pathogenesis-related genes. Here, we review features of the lamina and NPC across eukaryotes and discuss how these elements are structured in trypanosomes, protozoa of high medical and veterinary importance, highlighting lineage-specific and conserved aspects of nuclear organisation.
Trvalý link: https://hdl.handle.net/11104/0349355