Old Herborn University Seminar Monograph 35: Microbes impacting Mammalian systems biology

0580480 - MBÚ 2024 RIV DE eng M - Část monografie knihy
Schwarzer, Martin - Gautam, Umesh Kumar - Šrůtková, Dagmar - Leulier, F.
The role of the gut microbiota and Lactiplantibacillus plantarum wjl strain in Juvenile growth during chronic undernutrition
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Old Herborn University Seminar Monograph 35: Microbes impacting Mammalian systems biology. Herborn-Dill: Old Herborn University Foundation, 2023 - (Heidt, P.; Midtvedt, T.; Schwiertz, A.; Versalovic, J.; Rusch, V.), s. 17-23. Monograph 35. ISBN 3-923022-47-6
Grant CEP: GA ČR(CZ) GM21-19640M
GRANT EU: European Commission(DE) 4139 EMBO
Institucionální podpora: RVO:61388971
Klíčová slova: gut microbiota * Lactiplantibacillus plantarum * juvenile growth * undernutrition
Obor OECD: Immunology
https://www.old-herborn-university.de/wp-content/uploads/publications/books/OHUni_book_35_article_2.pdf

The World Health Organization defines malnutrition as a deficiency, excess, or imbalance in a person's energy and/or nutrient intake. However, it is becoming increasingly clear that not only diet per se, but also the intestinal microbiota plays a fundamental role in the development of diseases associated with malnutrition. Next-generation sequencing, the renewed interest in bac- terial culturing techniques, and the use of gnotobiotic models have enabled major advances in causally linking the role of the microbiota and specific
bacterial strains in the aetiology/prevention of diseases associated with undernutrition, including wasting, stunting, and underweight. We have shown that the Lactiplantibacillus plantarum strain, selected in the gnotobiotic invertebrate Drosophila model for its growth-promoting properties, is able to increase the growth of juvenile undernourished mice in both gnotobiotic and specific pathogen-free animals, and that this effect is dependent on the expression of the NOD2 receptor by intestinal epithelial cells. These results suggest that administration of selected bacterial strains may represent a novel strategy for alleviating the persistent stunting that is one of the long-term consequences of undernutrition, which still affects millions of children under five years of age in low- and middle-income countries.
Trvalý link: https://hdl.handle.net/11104/0349314