Počet záznamů: 1
Envisioning a role for nuclear actin in prophase I spermatocytes
- 1.0580243 - ÚMG 2024 RIV CH eng J - Článek v odborném periodiku
Petrusová, Jana - Manning, Jasper - Filipp, Dominik
Envisioning a role for nuclear actin in prophase I spermatocytes.
Frontiers in Cell and Developmental Biology. Roč. 11, Nov (2023), č. článku 1295452. ISSN 2296-634X. E-ISSN 2296-634X
Grant CEP: GA ČR(CZ) GA23-06605S
Institucionální podpora: RVO:68378050
Klíčová slova: binding proteins * f-actin * saccharomyces-cerevisiae * meiotic recombination * synaptonemal complex * chromatin-structure * focal adhesion * dna-repair * vinculin * ino80 * actin * prophase I * nucleoskeleton * chromatin remodeling * spermatoproteasome
Obor OECD: Immunology
Impakt faktor: 5.5, rok: 2022
Způsob publikování: Open access
https://www.frontiersin.org/articles/10.3389/fcell.2023.1295452/full
Actin is a multi-functional protein that is involved in numerous cellular processes including cytoskeleton regulation, cell migration, and cellular integrity. In these processes, actin's role in respect to its structure, complex mechanical, and protein-binding properties has been studied primarily in the cytoplasmic and cellular membrane compartments. However, its role in somatic cell nuclei has recently become evident where it participates in transcription, chromatin remodeling, and DNA damage repair. What remains enigmatic is the involvement of nuclear actin in physiological processes that lead to the generation of germ cells, in general, and primary spermatocytes, in particular. Here, we will discuss the possible role and nuclear localization of actin during meiotic prophase I and its interaction with chromatin remodeling complexes, the latter being essential for the control of pairing of homologous chromosomes, cross-over formation, and recombination. It is our hope that this perspective article will extend the scope of actin's nuclear function in germ cells undergoing meiotic division.
Trvalý link: https://hdl.handle.net/11104/0348993
Počet záznamů: 1