Microfluidic Nanospray Emitters with a Liquid Junction for Sensitive Bioanalyses

0579234 - ÚIACH 2024 US eng A - Abstrakt
Vereshchagina, E. - Václavek, Tomáš - Summanwar, A. - Moe, S. - Nazareno, L. - Sordo, G. - Nordborg, A. - Vogl, A. - Foret, František - Řemínek, Roman
Microfluidic Nanospray Emitters with a Liquid Junction for Sensitive Bioanalyses.
IEEE Sensors 2023 : Conference Program. 2023. s. 1-1.
[IEEE SENSORS 2023 /22./. 29.10.2023-01.11.2023, Vienna]
Grant CEP: GA TA ČR(CZ) TO01000232
Institucionální podpora: RVO:68081715
Klíčová slova: capillary electrophoresis * mass spectrometry * electrospray interface * MEMS * nanospray emitter
Obor OECD: Analytical chemistry
Způsob publikování: Omezený přístup
https://confcats-event-sessions.s3.amazonaws.com/sensors23/uploads/SENSORS_2023_Program.pdf

Mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS) are universal analytical techniques continuously expanding towards the biopharmaceutical, life sciences, and environmental industries. MS analysis is often used as a golden standard for benchmarking novel analytical devices and sensors. In the past three decades, microfabricated electrospray interfaces (ESI) coupled with MS evolved into a powerful tool, further streamlining bioanalytical procedures in many classical applications. Also, some innovative applications advancing due to miniaturization technologies, particularly organ-on-a-chip, single-cell and integrated sensors and actuators for portable mass spectrometers, benefit largely from the development of methodologies for direct coupling of miniaturized devices to MS. Despite several reported advances in the interfacing of standard sample separation (capillary electrophoresis (CE)) as well as various chip-based separation techniques and other chip modalities with MS, engineering an interface with steady performance using mass manufacturing techniques remains a considerable challenge. Among the existing interfacing approaches, microfabricated nanospray emitters (or nanosprayers) hold promises of superior ionization efficiency, stable signal below 100 nL/min, and therefore, higher sensitivity compared to standard methods.


Trvalý link: https://hdl.handle.net/11104/0348088