Microbiota as the unifying factor behind the hallmarks of cancer

0578527 - MBÚ 2024 RIV DE eng J - Článek v odborném periodiku
Benešová, Iva - Křížová, L. - Kverka, Miloslav
Microbiota as the unifying factor behind the hallmarks of cancer.
Journal of Cancer Research and Clinical Oncology. Roč. 149, č. 15 (2023), s. 14429-14450. ISSN 0171-5216. E-ISSN 1432-1335
Grant CEP: GA MZd(CZ) NV19-03-00179
Grant ostatní: AV ČR(CZ) LQ200202105
Program: Prémie Lumina quaeruntur
Institucionální podpora: RVO:61388971
Klíčová slova: regulatory t-cells * gut microbiota * fusobacterium-nucleatum * colorectal-cancer * intestinal microbiota * commensal bacteria * helicobacter-pylori * therapy efficacy * up-regulation * tumor-growth * Gut microbiota * Hallmarks of cancer * Tumor microenvironment * Fecal microbiota transplantation
Obor OECD: Oncology
Impakt faktor: 3.6, rok: 2022
Způsob publikování: Open access
https://link.springer.com/article/10.1007/s00432-023-05244-6

The human microbiota is a complex ecosystem that colonizes body surfaces and interacts with host organ systems, especially the immune system. Since the composition of this ecosystem depends on a variety of internal and external factors, each individual harbors a unique set of microbes. These differences in microbiota composition make individuals either more or less susceptible to various diseases, including cancer. Specific microbes are associated with cancer etiology and pathogenesis and several mechanisms of how they drive the typical hallmarks of cancer were recently identified. Although most microbes reside in the distal gut, they can influence cancer initiation and progression in distant tissues, as well as modulate the outcomes of established cancer therapies. Here, we describe the mechanisms by which microbes influence carcinogenesis and discuss their current and potential future applications in cancer diagnostics and management.
Trvalý link: https://hdl.handle.net/11104/0347518