Chronic Inflammation Promotes Cancer Progression as a Second hit.

0578355 - ÚMG 2024 RIV US eng J - Článek v odborném periodiku
Burocziová, Monika - Grušanovič, Srdjan - Vaníčková, Karolína - Kosanovič, Slaďana - Alberich-Jorda, Meritxell
Chronic Inflammation Promotes Cancer Progression as a Second hit.
Experimental Hematology. Roč. 128, Dec 23 (2023), s. 30-37. ISSN 0301-472X. E-ISSN 1873-2399
Grant CEP: GA ČR GA20-03380S; GA MŠMT LX22NPO5102
GRANT EU: European Commission(XE) 860002 - ENHPATHY
Institucionální podpora: RVO:68378050
Klíčová slova: CMO mice * cancer progression * Acute myeloid leukemia (AML)
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 2.6, rok: 2022
Způsob publikování: Open access
https://www.sciencedirect.com/science/article/pii/S0301472X23017022?via%3Dihub

Acute myeloid leukemia (AML) is a malignant neoplasia of the hematopoietic system characterized by the accumulation of immature and nonfunctional leukemic blasts in the bone marrow and peripheral tissues. Mechanistically, the development of AML is explained by the .two-hit. theory, which is based on the accumulation of driver mutations that will cooperate to induce transformation. However, a significant percentage of patients with AML exhibit only one driver mutation, and thus, how leukemic transformation occurs in these cases is unclear. Accumulating evidence suggests that nongenetic factors, such as chronic inflammation, might influence AML development, and accordingly, clinical data have reported that patients with chronic inflammatory disorders have an increased risk of developing hematological malignancies. Here, using a mouse model of chronic inflammation, we demonstrate that systemic elevated levels of cytokines and chemokines and hyperactivation of the Jak/Stat3 signaling pathway may substitute .second hit. mutations and accelerate tumorigenesis. Altogether, our data highlight chronic inflammation as an additional factor in the development of AML, providing additional understanding of the mechanisms of transformation and opening new avenues for the treatment of this disease.
Trvalý link: https://hdl.handle.net/11104/0348250