Miniaturized System for Capillary Electrophoresis Coupling with Mass Spectrometry Detection

0577798 - ÚIACH 2024 CZ eng A - Abstrakt
Řemínek, Roman - Václavek, Tomáš - Vereshchagina, E. - Vogl, A. - Foret, František
Miniaturized System for Capillary Electrophoresis Coupling with Mass Spectrometry Detection.
CECE 2023. 18th International Interdisciplinary Meeting on Bioanalysis. Brno: Ústav analytické chemie AV ČR, v. v. i., 2023. s. 68-68. ISBN 978-80-908154-0-7.
[CECE 2023. International Interdisciplinary Meeting on Bioanalysis /18./. 23.10.2023-25.10.2023, Brno]
Institucionální podpora: RVO:68081715
Klíčová slova: capillary electrophoresis (CE) * mass spectrometry (MS) * electrospray ionization (ESI)
Obor OECD: Analytical chemistry
https://www.ce-ce.org/user_uploads/CECE_2023/CECE%202023%20Proceedings.pdf

Mass spectrometry (MS) is a universal analytical technique continuously expanding towards the biopharmaceutical, life sciences, and other industries. MS analysis is often used as a golden standard for benchmarking of novel analytical devices and sensors. For its coupling with separation techniques, such as capillary electrophoresis (CE) or liquid chromatography, it is necessary to transfer the analytes from the liquid to the gas phase. Among a variety of available approaches, electrospray ionization (ESI) is the most frequently used. Whereas the standard sheath liquid ESI interfaces are commercially obtainable, the potential of nanoESI systems has not been fully explored. Due to ultra-low flow rates, typically below 100 nL/min, the nanoESI technology holds a promise of superior ionization efficiency and reduction of ion suppression.
Trvalý link: https://hdl.handle.net/11104/0346892