UHPLC-MS Analysis of Salivary Bile Acids in Non-Invasive Diagnostics of Barrett’s Esophagus

0577621 - ÚIACH 2024 CZ eng A - Abstrakt
Dosedělová, Věra - Laštovičková, Markéta - Dolina, J. - Konečný, Š. - Kubáň, Petr … celkem 6 autorů
UHPLC-MS Analysis of Salivary Bile Acids in Non-Invasive Diagnostics of Barrett’s Esophagus.
CECE 2023. 18th International Interdisciplinary Meeting on Bioanalysis. Brno: Ústav analytické chemie AV ČR, v. v. i., 2023. s. 47-47. ISBN 978-80-908154-0-7.
[CECE 2023. International Interdisciplinary Meeting on Bioanalysis /18./. 23.10.2023-25.10.2023, Brno]
Grant CEP: GA MZd(CZ) NU23-08-00303
Institucionální podpora: RVO:68081715
Klíčová slova: UHPLC-MS * cascade blue hydrazide * Barrett’s esophagus
Obor OECD: Analytical chemistry
https://www.ce-ce.org/user_uploads/CECE_2023/CECE%202023%20Proceedings.pdf

Barrett’s esophagus (BE) is a serious complication of severe gastroesophageal reflux disease and a major risk factor for the development of esophageal cancer. The diagnosis of BE currently involves invasive endoscopy with sample collection and histological examination. Bile acids, a group of steroid compounds, were previously suggested to contribute to the progression of gastroesophageal reflux disease into BE. Bile acids are essential for lipid digestion in the small intestine, however due to their detergent properties they are toxic in high concentrations. This work is focused on development of methodology for analysis of bile acids in saliva and its possible application for a non-invasive diagnosis of BE.
Trvalý link: https://hdl.handle.net/11104/0346748