Alterations of sleep initiation in NREM parasomnia after sleep deprivation – A multimodal pilot study

0577250 - ÚI 2024 RIV NL eng J - Článek v odborném periodiku
Miletínová, E. - Piorecký, M. - Koudelka, V. - Jiříček, Stanislav - Tomeček, David - Brunovský, M. - Horáček, J. - Bušková, J.
Alterations of sleep initiation in NREM parasomnia after sleep deprivation – A multimodal pilot study.
Sleep Medicine: X. Roč. 6, December 2023 (2023), č. článku 100086. ISSN 2590-1427
Institucionální podpora: RVO:67985807
Klíčová slova: Disorders of arousal * Functional brain imaging * HdEEG and fMRI integration * High density EEG * Parasomnias * Slow wave sleep
Obor OECD: Neurosciences (including psychophysiology
Způsob publikování: Open access
https://dx.doi.org/10.1016/j.sleepx.2023.100086

OBJECTIVES: NREM parasomnias also known as disorders of arousal (DOA) are characterised by abnormal motor and autonomic activation during arousals primarily from slow wave sleep. Dissociative state between sleep and wake is likely responsible for clinical symptoms of DOA. We therefore investigated potential dissociation outside of parasomnic events by using simultaneous 256-channel EEG (hdEEG) and functional magnetic resonance imaging (fMRI). METHODS: Eight DOA patients (3 women, mean age = 27.8, SD = 4.2) and 8 gender and age matched healthy volunteers (3 women, mean age = 26,5, SD = 4.0) were included into the study. They underwent 30–32 h of sleep deprivation followed by hdEEG and fMRI recording. We determined 2 conditions: falling asleep (FA) and arousal (A), that occurred outside of deep sleep and/or parasomnic event. We used multimodal approach using data obtained from EEG, fMRI and EEG-fMRI integration approach. RESULTS: DOA patients showed increase in delta and beta activity over postcentral gyrus and cuneus during awakening period. This group expressed increased connectivity between motor cortex and cingulate during arousals unrelated to parasomnic events in the beta frequency band. They also showed lower connectivity between different portions of cingulum. In contrast, the greater connectivity was found between thalamus and some cortical areas, such as occipital cortex. CONCLUSION: Our findings suggest a complex alteration in falling asleep and arousal mechanisms at both subcortical and cortical levels in response to sleep deprivation. As this alteration is present also outside of slow wave sleep and/or parasomnic episodes we believe this could be a trait factor of DOA.
Trvalý link: https://hdl.handle.net/11104/0346463