Počet záznamů: 1  

Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context

  1. 1.
    0576584 - BFÚ 2024 RIV US eng J - Článek v odborném periodiku
    Šponer, Judit E. - Šponer, Jiří - Výravský, J. - Matyášek, Roman - Kovařík, Aleš - Dudziak, W. - Slepokura, K.
    Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context.
    iScience. Roč. 26, č. 9 (2023), č. článku 107600. E-ISSN 2589-0042
    Grant CEP: GA ČR(CZ) GA22-25057S
    Institucionální podpora: RVO:68081707
    Klíčová slova: 3′,5′cGMP * 3′,5′cCMP (free acid) readily crystallize from nucleotide mixtures * Crystallization could sequester 3′,5′cGMP * 3′,5′cCMP from the prebiotic soup * 3′,5′cCMP and 3′,5′cGMP phase-separate upon dry-wet cycling
    Obor OECD: Organic chemistry
    Impakt faktor: 5.8, rok: 2022
    Způsob publikování: Open access
    https://www.sciencedirect.com/science/article/pii/S2589004223016772?via%3Dihub

    Accumulation and selection of nucleotides is one of the most challenging problems surrounding the origin of the first RNA molecules on our planet. In the current work we propose that guanosine 3',5' cyclic mono phosphate could selectively crystallize upon evaporation of an acidic prebiotic pool containing various other nucleotides. The conditions of the evaporative crystallization are fully compatible with the subsequent acid catalyzed polymerization of this cyclic nucleotide reported in earlier studies and may be relevant in a broad range of possible prebiotic environments. Albeit cytidine 3',5' cyclic monophosphate has the ability to selectively accumulate under the same conditions, its crystal structure is not likely to support polymer formation.
    Trvalý link: https://hdl.handle.net/11104/0349241

     
     
Počet záznamů: 1  

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