0576569 - BC 2024 RIV GB eng J - Journal Article
Field, Mark Christian
Deviating from the norm: Nuclear organisation in trypanosomes.
Current Opinion in Cell Biology. Roč. 85, DEC (2023), č. článku 102234. ISSN 0955-0674. E-ISSN 1879-0410
Institutional support: RVO:60077344
Keywords : Lamins * Lamina * Nuclear architecture * Nuclear envelope * Molecular evolution * Eukaryogenesis * Nuclear pore complex * Trypanosomes
OECD category: Cell biology
Impact factor: 6, year: 2023 ; AIS: 2.776, rok: 2023
Method of publishing: Open access
Result website:
https://www.sciencedirect.com/science/article/pii/S0955067423000832?via%3DihubDOI: https://doi.org/10.1016/j.ceb.2023.102234

At first glance the nucleus is a highly conserved organelle. Overall nuclear morphology, the octagonal nuclear pore complex, the presence of peripheral heterochromatin and the nuclear envelope appear near constant features right down to the ultrastructural level. New work is revealing significant compositional divergence within these nuclear structures and their associated functions, likely reflecting adaptations and distinct mechanisms between eukaryotic lineages and especially the trypanosomatids. While many examples of mechanistic divergence currently lack obvious functional interpretations, these studies underscore the malleability of nuclear architecture. I will discuss some recent findings highlighting these facets within trypanosomes, together with the underlying evolutionary framework and make a call for the exploration of nuclear function in non-canonical experimental organisms.
Permanent Link: https://hdl.handle.net/11104/0346300