Allergic reactions to tick saliva components in zebrafish model

0576496 - BC 2024 RIV GB eng J - Článek v odborném periodiku
Contreras, M. - Vaz-Rodrigues, R. - Mazuecos, L. - Villar, M. - Artigas-Jerónimo, S. - Gonzalez-Garcia, A. - Shilova, N.V. - Bovin, N.V. - Diaz-Sanchez, S. - Ferreras-Colino, E. - Pacheco, I. - Chmelař, J. - Kopáček, Petr - Cabezas-Cruz, A. - Gortazar, C. - de la Fuente, J.
Allergic reactions to tick saliva components in zebrafish model.
Parasites & Vectors. Roč. 16, č. 1 (2023), č. článku 242. ISSN 1756-3305. E-ISSN 1756-3305
Institucionální podpora: RVO:60077344
Klíčová slova: Allergy * Alpha-gal syndrome * Glycan * Tick * Zebrafish
Obor OECD: Tropical medicine
Impakt faktor: 3.2, rok: 2022
Způsob publikování: Open access
https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-023-05874-2

Background Alpha-Gal syndrome (AGS) is a tick-borne food allergy caused by IgE antibodies against the glycan galactose-alpha-1,3-galactose (a-Gal) present in glycoproteins and glycolipids from mammalian meat. To advance in the diagnosis and treatment of AGS, further research is needed to unravel the molecular and immune mechanisms underlying this syndrome. The objective of this study is the characterization of tick salivary components and proteins with and without alpha-Gal modifications involved in modulating human immune response against this carbohydrate.
Trvalý link: https://hdl.handle.net/11104/0346050