Počet záznamů: 1  

Modelling Duchenne muscular dystrophy in vitro with newly generated, blood cell-derived induced pluripotent stem cell line ORIONi003-A

  1. 1.
    0576442 - ÚŽFG 2024 RIV NL eng J - Článek v odborném periodiku
    Hajdúchová, D. - Suroviaková, S. - Meršaková, S. - Braný, D. - Záhumenská, R. - Řehák, M. - Skovierová, H. - Nováková, S. - Nosál, V. - Marcínek, J. - Kalman, M. - Pec, M. J. - Brozmanova, M. - Melegová, J. - Juhás, Štefan - Juhásová, Jana - Studenovská, Hana - Mitrušková, B. - Pokusa, M. - Samec, M. - Samos, M. - Nicodemou, A. - Danišovič, L. - Danková, Z. - Kurča, E. - Lexová Kolejaková, K. - Chandoga, J. - Plank, L. - Halašová, E. - Pecová, R. - Strnádel, J.
    Modelling Duchenne muscular dystrophy in vitro with newly generated, blood cell-derived induced pluripotent stem cell line ORIONi003-A.
    Stem Cell Research. Roč. 71, Sept 23 (2023), č. článku 103187. ISSN 1873-5061. E-ISSN 1876-7753
    Institucionální podpora: RVO:67985904 ; RVO:61389013
    Klíčová slova: Duchenne muscular dystrophy * in vitro
    Obor OECD: Cell biology; Polymer science (UMCH-V)
    Impakt faktor: 1.2, rok: 2022
    Způsob publikování: Open access
    https://www.sciencedirect.com/science/article/pii/S1873506123001733?via%3Dihub

    Here, we present newly derived in vitro model for modeling Duchenne muscular dystrophy. Our new cell line was derived by reprogramming of peripheral blood mononuclear cells (isolated from blood from pediatric patient) with Sendai virus encoding Yamanaka factors. Derived iPS cells are capable to differentiate in vitro into three germ layers as verified by immunocytochemistry. When differentiated in special medium, our iPSc formed spontaneously beating cardiomyocytes. As cardiomyopathy is the main clinical complication in patients with Duchenne muscular dystrophy, the cell line bearing the dystrophin gene mutation might be of interest to the research community.
    Trvalý link: https://hdl.handle.net/11104/0345978

     
     
Počet záznamů: 1  

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