Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform

0576245 - ÚOCHB 2024 RIV NL eng J - Článek v odborném periodiku
Alfandari, D. - Cadury, S. - Morandi, Mattia I. - Regev-Rudzki, N.
Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform.
Trends in Parasitology. Roč. 39, č. 11 (2023), s. 913-928. ISSN 1471-4922. E-ISSN 1471-5007
Institucionální podpora: RVO:61388963
Klíčová slova: extracellular vesicles * infectious diseases * parasites * vaccine
Obor OECD: Physical chemistry
Impakt faktor: 9.6, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.pt.2023.08.009

Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic infections. We here present achievements to date and the challenges and limitations associated with using parasitic EVs in a clinical context. Despite the many difficulties that need to be overcome, we believe this direction could offer a new and reliable source of therapeutics for various neglected parasitic diseases.
Trvalý link: https://hdl.handle.net/11104/0345821