Tick-borne encephalitis: A comprehensive review of the epidemiology, virology, and clinical picture

0576093 - BC 2024 RIV GB eng J - Článek v odborném periodiku
Chiffi, G. - Grandgirard, D. - Leib, S.L. - Chrdle, A. - Růžek, Daniel
Tick-borne encephalitis: A comprehensive review of the epidemiology, virology, and clinical picture.
Reviews in Medical Virology. Roč. 33, SEPT (2023), č. článku 5. ISSN 1052-9276. E-ISSN 1099-1654
Grant CEP: GA ČR(CZ) GA20-14325S
Institucionální podpora: RVO:60077344
Klíčová slova: epidemiology * immune response * molecular pathogenesis * neurological sequela * tick-borne encephalitis * tick-borne encephalitis virus
Obor OECD: Virology
Impakt faktor: 11.1, rok: 2022
Způsob publikování: Omezený přístup
https://onlinelibrary.wiley.com/doi/10.1002/rmv.2470

Tick-borne encephalitis virus (TBEV) is a flavivirus commonly found in at least 27 European and Asian countries. It is an emerging public health problem, with steadily increasing case numbers over recent decades. Tick-borne encephalitis virus affects between 10,000 and 15,000 patients annually. Infection occurs through the bite of an infected tick and, much less commonly, through infected milk consumption or aerosols. The TBEV genome comprises a positive-sense single-stranded RNA molecule of & SIM,11 kilobases. The open reading frame is > 10,000 bases long, flanked by untranslated regions (UTR), and encodes a polyprotein that is co- and post-transcriptionally processed into three structural and seven non-structural proteins. Tick-borne encephalitis virus infection results in encephalitis, often with a characteristic biphasic disease course. After a short incubation time, the viraemic phase is characterised by non-specific influenza-like symptoms. After an asymptomatic period of 2-7 days, more than half of patients show progression to a neurological phase, usually characterised by central and, rarely, peripheral nervous system symptoms. Mortality is low-around 1% of confirmed cases, depending on the viral subtype. After acute tick-borne encephalitis (TBE), a minority of patients experience long-term neurological deficits. Additionally, 40%-50% of patients develop a post-encephalitic syndrome, which significantly impairs daily activities and quality of life. Although TBEV has been described for several decades, no specific treatment exists. Much remains unknown regarding the objective assessment of long-lasting sequelae. Additional research is needed to better understand, prevent, and treat TBE. In this review, we aim to provide a comprehensive overview of the epidemiology, virology, and clinical picture of TBE.
Trvalý link: https://hdl.handle.net/11104/0346043