A Role of PI3K/Akt Signaling in Oocyte Maturation and Early Embryo Development

0574404 - ÚŽFG 2024 RIV CH eng J - Článek v odborném periodiku
Kalous, Jaroslav - Aleshkina, Daria - Anger, Martin
A Role of PI3K/Akt Signaling in Oocyte Maturation and Early Embryo Development.
Cells. Roč. 12, č. 14 (2023), č. článku 1830. E-ISSN 2073-4409
Grant CEP: GA MŠMT EF15_003/0000460; GA ČR(CZ) GA22-27301S
Institucionální podpora: RVO:67985904
Klíčová slova: Akt kinase * mTORC1 * mitosis * meiosis * spindle
Obor OECD: Developmental biology
Impakt faktor: 6, rok: 2022
Způsob publikování: Open access
https://www.mdpi.com/2073-4409/12/14/1830

A serine/threonine-specific protein kinase B (PKB), also known as Akt, is a key factor in the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway that regulates cell survival, metabolism and proliferation. Akt phosphorylates many downstream specific substrates, which subsequently control the nuclear envelope breakdown (NEBD), centrosome maturation, spindle assembly, chromosome segregation, and cytokinesis. In vertebrates, Akt is also an important player during oogenesis and preimplantation development. In the signaling pathways regulating mRNA translation, Akt is involved in the control of mammalian target of rapamycin complex 1 (mTORC1) and thereby regulates the activity of a translational repressor, the eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1). In this review, we summarize the functions of Akt in mitosis, meiosis and early embryonic development. Additionally, the role of Akt in the regulation of mRNA translation is addressed with respect to the significance of this process during early development.
Trvalý link: https://hdl.handle.net/11104/0344732