Investigation of novel Mn(ıı) fenamato complexes with neocuproine and their effects on endometrial cell lines

0574225 - FZÚ 2024 RIV GB eng J - Článek v odborném periodiku
Klepcová, Z. - Špaková, I. - Madreiter-Sokolowski, C.T. - Graier, W. - Kalinová, K. - Samoľová, Erika - Smolková, R. - Smolko, L. - Rabajdová, M.
Investigation of novel Mn(ıı) fenamato complexes with neocuproine and their effects on endometrial cell lines.
New Journal of Chemistry. Roč. 47, č. 28 (2023), s. 13088-13097. ISSN 1144-0546. E-ISSN 1369-9261
Grant CEP: GA MŠMT(CZ) LM2018096
Institucionální podpora: RVO:68378271
Klíčová slova: Mn(ıı) complexes * neocuproine * crystal structure * x-ray diffraction * cytotoxic effect
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 3.3, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.1039/d3nj00412k

Two novel Mn(ıı) complexes with non-steroidal anti-inflammatory drugs, fenamic (Hfen = 2-(phenylamino) benzoic acid) and flufenamic acid (Hflu = N-(3-trifluoromethylphenyl)-2-aminobenzoic acid) and neocuproine (neo) as a supporting ligand were designed, synthesized and characterized. Their molecular structure was determined by the single-crystal X-ray diffraction method. The cytotoxic effects of the complexes were studied on three selected cell lines, including epithelial hTERT HME1 used as a healthy control, endometriotic 12Z and endometrial cancer SK-UT-1.
Trvalý link: https://hdl.handle.net/11104/0344568