Počet záznamů: 1
Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells
- 1.0574081 - ÚVGZ 2024 RIV NL eng J - Článek v odborném periodiku
Labohá, P. - Sychrová, E. - Brózman, O. - Sovadinová, I. - Bláhová, L. - Prokeš, Roman - Ondráček, Jakub - Babica, Pavel
Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells.
Environmental Toxicology and Pharmacology. Roč. 98, MAR (2023), č. článku 104073. ISSN 1382-6689. E-ISSN 1872-7077
Výzkumná infrastruktura: CzeCOS IV - 90248
Institucionální podpora: RVO:86652079 ; RVO:67985858 ; RVO:67985939
Klíčová slova: Aerosol * Cyanobacteria * Cyanotoxins * Lipopolysaccharides * Inflammation * Inhalation toxicity
Obor OECD: Environmental sciences (social aspects to be 5.7); Environmental sciences (social aspects to be 5.7) (UCHP-M); Environmental sciences (social aspects to be 5.7) (BU-J)
Impakt faktor: 4.3, rok: 2022
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S1382668923000145?via%3Dihub
Components of cyanobacterial water blooms were quantified in aerosols above agitated water surfaces of five freshwater bodies. The thoracic and respirable aerosol fraction (0.1–10 µm) was sampled using a high-volume sampler. Cyanotoxins microcystins were detected by LC-MS/MS at levels 0.3–13.5 ng/mL (water) and < 35–415 fg/m3 (aerosol). Lipopolysaccharides (endotoxins) were quantified by Pyrogene rFC assay at levels < 10–119 EU/mL (water) and 0.13–0.64 EU/m3 (aerosol). Cyanobacterial DNA was detected by qPCR at concentrations corresponding to 104–105 cells eq./mL (water) and 101–103 cells eq./m3 (aerosol). Lipopolysaccharides isolated from bloom samples induced IL-6 and IL-8 cytokine release in human bronchial epithelial cells Beas-2B, while extracted cyanobacterial metabolites induced both pro-inflammatory and cytotoxic effects. Bloom components detected in aerosols and their bioactivities observed in upper respiratory airway epithelial cells together indicate that aerosols formed during cyanobacterial water blooms could induce respiratory irritation and inflammatory injuries, and thus present an inhalation health risk.
Trvalý link: https://hdl.handle.net/11104/0344445
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Počet záznamů: 1