Plasmatic apelin shows a promising potential as a screening biomarker for atrial fibrillation

0573133 - ÚI 2024 RIV SK eng J - Článek v odborném periodiku
Bezák, B. - Snopek, P. - Tóthová, L. - Jajcay, Nikola - Mojto, V. - Farský, Š. - Gmitterová, K. - Krivošík, M. - Stanková, S. - Duraníková, O. - Kollárová, M. - Petríková, K. - Böhm, A.
Plasmatic apelin shows a promising potential as a screening biomarker for atrial fibrillation.
Bratislavske Lekarske Listy. Roč. 124, č. 5 (2023), s. 368-372. ISSN 0006-9248. E-ISSN 1336-0345
Institucionální podpora: RVO:67985807
Klíčová slova: biomarker * apelin * arrhythmia * atrial fibrillation
Obor OECD: Cardiac and Cardiovascular systems
Impakt faktor: 1.5, rok: 2022
Způsob publikování: Open access
https://dx.doi.org/10.4149/BLL_2023_056

OBJECTIVES: Purpose of this study was to evaluate properties of apelin, a peptide detectable in peripheral blood, for atrial fibrillation (AF) detection in a diverse population of patients covering a broad spectrum from healthy to polymorbid patients. BACKGROUND: AF is the most common cardiac arrhythmia with constantly increasing incidence and prevalence. Currently available diagnostic tools do not provide sufficient detection rate. Large proportion of patients with AF remains undiagnosed and the possibility of screening at-risk groups would be significantly beneficial. METHODS: We designed this study as a multi-centre retrospective study. Study population included 183 patients. 64 in non-AF and 119 in AF group. RESULTS: Apelin plasma concentration was significantly lower in AF group compared to non-AF group (p < 0.001). Receiver operating characteristic analysis of apelin as a predictor of AF scored area under the curve of 0.79, sensitivity = 0.941 and specificity = 0.578. Multivariate analysis using logistic regression adjusted for age, BMI, apelin, dilated LV, dilated LA, arterial hypertension, and gender showed only apelin and age to be statistically significant contributors for AF. CONCLUSION: Apelin might be a promising biomarker for detecting AF in our study population. These results suggest promising potential of apelin as a screening biomarker for AF (Tab. 2, Fig. 1, Ref. 46).
Trvalý link: https://hdl.handle.net/11104/0343599