Application of In situ TR Spectroelectrochemical Techniques in Determination of Redox Mechanism of Bioactive Compounds

0572822 - ÚFCH JH 2025 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
Sokolová, Romana - Jiroušková, Eliška - Degano, I. - Wantulok, J. - Nycz, J.
Application of In situ TR Spectroelectrochemical Techniques in Determination of Redox Mechanism of Bioactive Compounds.
Moderní elektrochemické metody /42./. Sborník přednášek. Ústí nad Labem: Best servis, 2023 - (Navrátil, T.; Fojta, M.; Schwarzová, K.), s. 186-190. ISBN 978-80-908947-0-9.
[Moderní elektrochemické metody /42./. Jetřichovice (CZ), 22.05.2023-26.05.2023]
Institucionální podpora: RVO:61388955
Klíčová slova: IR spectroelectrochemistry * psychoactive substances * oxidation mechanism
Obor OECD: Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

The electron transfer reactions play an important role in many natural processes. Reactions such as
dissociation, protonation, and reactions with water and other small molecules often occur in
biotransformation. The reaction schemes involving these chemical reactions coupled to the
electron transfer can be determined by cyclic voltammetry. Additionally, in
situ spectroelectrochemistry can efficiently contribute to the determination of oxidation or
reduction mechanism. This technique provides information about the electroactive chromophore during
the redox process allowing to identification the first reaction intermediates. The final reaction
products were identified by chromatographic techniques. This study represents a key role of TR
spectroelectrochemistry in the determination of reaction intermediates in the case of
1,10- phenanthroline derivative substituted by bioactive phenothiazine unit and
drug 3- fluorophenmetrazine (2-(3-fluorophenyl)-3-methylmorpholine, 3-FPM). Co pound 3-FPM
have recently appeared as the new psychoactive substance in the drug market.

Trvalý link: https://hdl.handle.net/11104/0343385