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Organoruthenium glycomimetics as selective galectin-1 inhibitors
- 1.0572638 - ÚCHP 2024 CZ eng K - Konferenční příspěvek (tuzemská konf.)
Hamala, Vojtěch
Organoruthenium glycomimetics as selective galectin-1 inhibitors.
Proceedings of Abstracts. Prague: Institute of Chemical Process Fundamentals of the CAS, v. v. i., 2023 - (Bendová, M.; Wagner, Z.; Windell, L.), s. 13-14. ISBN 978-80-86186-29-0.
[Bažant postraguate conference 2023. Prague (CZ), 31.05.2023-01.06.2023]
Grant CEP: GA ČR(CZ) GA23-06115S
Institucionální podpora: RVO:67985858
Klíčová slova: galectin inhibitors * glycomimetcs * carbohydrates
Obor OECD: Organic chemistry
The prepared organoruthenium glycomimetics demonstrated sin gle unit nanomolar affinity to Gal-1 and over four orders of magnitude
higher selectivity to Gal-1 in comparison to Gal-3. The organoruthe nium galectin inhibitors were found to be nontoxic to both cancer and
noncancerous cell lines. Selected complexes showed an in vitro an timigratory effect against invasive cancer cell lines MDA-MB-231 and
SK-OV-3.
Trvalý link: https://hdl.handle.net/11104/0343241
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