Energy partitioning in multicomponent nanoscintillators for enhanced localized radiotherapy

0572337 - FZÚ 2024 RIV US eng J - Článek v odborném periodiku
Secchi, V. - Cova, F. - Villa, Irene - Babin, Vladimir - Nikl, Martin - Campione, M. - Monguzzi, A.
Energy partitioning in multicomponent nanoscintillators for enhanced localized radiotherapy.
ACS Applied Materials and Interfaces. Roč. 15, č. 20 (2023), s. 24693-24700. ISSN 1944-8244. E-ISSN 1944-8252
Grant CEP: GA MŠMT(CZ) EF16_019/0000760
GRANT EU: European Commission(XE) 101003405 - HANSOME
Grant ostatní: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institucionální podpora: RVO:68378271
Klíčová slova: radiotherapy * scintillators * energy transfer * singlet oxygen * nanomaterials
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 9.5, rok: 2022
Způsob publikování: Open access

Multicomponent nanomaterials consisting of dense scintillating particles functionalized by or embedding optically active conjugated photosensitizers (PSs) for cytotoxic reactive oxygen species (ROS) have been proposed in the last decade as coadjuvant agents for radiotherapy of cancer. We investigate this mechanism in a series of PS-functionalized scintillating nanotubes where the non-radiative energy transfer yield has been tuned by control of the intermolecular distance between the nanotube and the conjugated system. The obtained results indicate that non-radiative energy transfer has a negligible effect on the ROS sensitization efficiency, thus opening the way to the development of different architectures for breakthrough radiotherapy coadjutants to be tested in clinics.
Trvalý link: https://hdl.handle.net/11104/0343087