Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone

0571763 - ÚPT 2024 RIV US eng J - Článek v odborném periodiku
Trávníček, Vojtěch - Klimeš, Petr - Cimbálník, J. - Halámek, Josef - Jurák, Pavel - Brinkmann, B. - Balzekas, I. - Abdallah, C. - Dubeau, F. - Frauscher, B. - Worrell, G. A. - Brázdil, M.
Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone.
Epilepsia. Roč. 64, č. 4 (2023), s. 962-972. ISSN 0013-9580. E-ISSN 1528-1167
Grant CEP: GA MZd(CZ) NU22-08-00278; GA ČR(CZ) GA22-28784S; GA ČR(CZ) GA21-25953S; GA MŠMT(CZ) LX22NPO5107; GA MŠMT(CZ) LTAUSA18056
Institucionální podpora: RVO:68081731
Klíčová slova: drug-resistant epilepsy * iEEG * SOZ localization
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 5.6, rok: 2022
Způsob publikování: Open access
https://onlinelibrary.wiley.com/doi/10.1111/epi.17539

Objective: High-frequency oscillations are considered among the most promising interictal biomarkers of the epileptogenic zone in patients suffering from pharmacoresistant focal epilepsy. However, there is no clear definition of pathological high-frequency oscillations, and the existing detectors vary in methodology, performance, and computational costs. This study proposes relative entropy as an easy-to-use novel interictal biomarker of the epileptic tissue.Methods: We evaluated relative entropy and high-frequency oscillation biomarkers on intracranial electroencephalographic data from 39 patients with seizure-free postoperative outcome (Engel Ia) from three institutions. We tested their capability to localize the epileptogenic zone, defined as resected contacts located in the seizure onset zone. The performance was compared using areas under the receiver operating curves (AUROCs) and precision-recall curves. Then we tested whether a universal threshold can be used to delineate the epileptogenic zone across patients from different institutions.Results: Relative entropy in the ripple band (80-250 Hz) achieved an average AUROC of .85. The normalized high-frequency oscillation rate in the ripple band showed an identical AUROC of .85. In contrast to high-frequency oscillations, relative entropy did not require any patient-level normalization and was easy and fast to calculate due to its clear and straightforward definition. One threshold could be set across different patients and institutions, because relative entropy is independent of signal amplitude and sampling frequency.Significance: Although both relative entropy and high-frequency oscillations have a similar performance, relative entropy has significant advantages such as straightforward definition, computational speed, and universal interpatient threshold, making it an easy-to-use promising biomarker of the epileptogenic zone.
Trvalý link: https://hdl.handle.net/11104/0344831