Počet záznamů: 1
Interaction between nanomaterials and the innate immune system across evolution
- 1.0571675 - MBÚ 2024 RIV US eng J - Článek v odborném periodiku
Boraschi, D. - Canesi, L. - Drobne, D. - Kemmerling, B. - Pinsino, A. - Procházková, Petra
Interaction between nanomaterials and the innate immune system across evolution.
Biological Reviews. Roč. 98, č. 3 (2023), s. 747-774. ISSN 1464-7931. E-ISSN 1469-185X
Grant CEP: GA MŠMT(CZ) LO1509
GRANT EU: European Commission(XE) 671881 - PANDORA
Institucionální podpora: RVO:61388971
Klíčová slova: innate immunity * Toll-like receptors * phagocytes * plants * invertebrates * human * in vivo * in vitro
Obor OECD: Immunology
Impakt faktor: 10, rok: 2022
Způsob publikování: Open access
https://onlinelibrary.wiley.com/doi/10.1111/brv.12928
Interaction of engineered nanomaterials (ENMs) with the immune system mainly occurs with cells and molecules of innate immunity, which are present in interface tissues of living organisms. Immuno-nanotoxicological studies aim at understanding if and when such interaction is inconsequential or may cause irreparable damage. Since innate immunity is the first line of immune reactivity towards exogenous agents and is highly conserved throughout evolution, this review focuses on the major effector cells of innate immunity, the phagocytes, and their major sensing receptors, Toll-like receptors (TLRs), for assessing the modes of successful versus pathological interaction between ENMs and host defences. By comparing the phagocyte- and TLR-dependent responses to ENMs in plants, molluscs, annelids, crustaceans, echinoderms and mammals, we aim to highlight common recognition and elimination mechanisms and the general sufficiency of innate immunity for maintaining tissue integrity and homeostasis.
Trvalý link: https://hdl.handle.net/11104/0343234
Počet záznamů: 1