Prediction of Pathologic Change Development in the Pancreas Associated with Diabetes Mellitus Assessed by NMR Metabolomics

0570912 - ÚCHP 2024 RIV US eng J - Článek v odborném periodiku
Michálková, Lenka - Horník, Štěpán - Sýkora, J. - Setnička, V. - Bunganič, B.
Prediction of Pathologic Change Development in the Pancreas Associated with Diabetes Mellitus Assessed by NMR Metabolomics.
Journal of Proteome Research. Roč. 22, č. 6 (2023), s. 1936-1946. ISSN 1535-3893. E-ISSN 1535-3907
Institucionální podpora: RVO:67985858
Klíčová slova: pancreatic cancer * NMR metabolomics * diabetes mellitus * prediction of pathologic changes
Obor OECD: Analytical chemistry
Impakt faktor: 4.4, rok: 2022
Způsob publikování: Open access
https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.3c00047

Nuclear magnetic resonance (NMR) metabolomics was used for identification of metabolic changes in pancreatic cancer (PC) blood plasma samples when compared to healthy controls or diabetes mellitus patients. An increased number of PC samples enabled a subdivision of the group according to individual PC stages and the construction of predictive models for finer classification of at-risk individuals recruited from patients with recently diagnosed diabetes mellitus. High-performance values of orthogonal partial least squares (OPLS) discriminant analysis were found for discrimination between individual PC stages and both control groups. The discrimination between early and metastatic stages was achieved with only 71.5% accuracy. A predictive model based on discriminant analyses between individual PC stages and the diabetes mellitus group identified 12 individuals out of 59 as at-risk of development of pathological changes in the pancreas, and four of them were classified as at moderate risk.
Trvalý link: https://hdl.handle.net/11104/0342241