Počet záznamů: 1  

On the origin of the functional versatility of macrophages

  1. 1.
    0570815 - BC 2024 RIV CH eng J - Článek v odborném periodiku
    Bajgar, Adam - Krejčová, Gabriela
    On the origin of the functional versatility of macrophages.
    Frontiers in Physiology. Roč. 14, FEB 23 (2023), č. článku 1128984. ISSN 1664-042X. E-ISSN 1664-042X
    Institucionální podpora: RVO:60077344
    Klíčová slova: Dictyostelium * acanthamoeba * Drosophila
    Obor OECD: Cell biology
    Impakt faktor: 4, rok: 2022
    Způsob publikování: Open access
    https://www.frontiersin.org/articles/10.3389/fphys.2023.1128984/pdf

    Macrophages represent the most functionally versatile cells in the animal body. In addition to recognizing and destroying pathogens, macrophages remove senescent and exhausted cells, promote wound healing, and govern tissue and metabolic homeostasis. In addition, many specialized populations of tissue-resident macrophages exhibit highly specialized functions essential for the function of specific organs. Sometimes, however, macrophages cease to perform their protective function and their seemingly incomprehensible response to certain stimuli leads to pathology. In this study, we address the question of the origin of the functional versatility of macrophages. To this end, we have searched for the evolutionary origin of macrophages themselves and for the emergence of their characteristic properties. We hypothesize that many of the characteristic features of proinflammatory macrophages evolved in the unicellular ancestors of animals, and that the functional repertoire of macrophage-like amoebocytes further expanded with the evolution of multicellularity and the increasing complexity of tissues and organ systems. We suggest that the entire repertoire of macrophage functions evolved by repurposing and diversification of basic functions that evolved early in the evolution of metazoans under conditions barely comparable to that in tissues of multicellular organisms. We believe that by applying this perspective, we may find an explanation for the otherwise counterintuitive behavior of macrophages in many human pathologies.
    Trvalý link: https://hdl.handle.net/11104/0349829

     
     
Počet záznamů: 1  

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