Počet záznamů: 1  

SART3 associates with a post-splicing complex

  1. 1.
    0570767 - ÚMG 2024 RIV GB eng J - Článek v odborném periodiku
    Klimešová, Klára - Petržílková, Hana - Bařinka, Cyril - Staněk, David
    SART3 associates with a post-splicing complex.
    Journal of Cell Science. Roč. 136, č. 2 (2023), č. článku jcs260380. ISSN 0021-9533. E-ISSN 1477-9137
    Grant CEP: GA ČR GA21-04132S
    Institucionální podpora: RVO:68378050 ; RVO:86652036
    Klíčová slova: Splicing * Recycling * U6 snRNA * U2 snRNP
    Obor OECD: Cell biology
    Impakt faktor: 4, rok: 2022
    Způsob publikování: Omezený přístup
    https://journals.biologists.com/jcs/article-abstract/136/2/jcs260380/286729/SART3-associates-with-a-post-splicing-complex?redirectedFrom=fulltext

    SART3 is a multifunctional protein that acts in several steps of gene expression, including assembly and recycling of the spliceosomal U4/ U6 small nuclear ribonucleoprotein particle (snRNP). In this work, we provide evidence that SART3 associates via its N-terminal HAT domain with the 12S U2 snRNP. Further analysis showed that SART3 associates with the post-splicing complex containing U2 and U5 snRNP components. In addition, we observed an interaction between SART3 and the RNA helicase DHX15, which disassembles post-splicing complexes. Based on our data, we propose a model that SART3 associates via its N-terminal HAT domain with the post-splicing complex, where it interacts with U6 snRNA to protect it and to initiate U6 snRNA recycling before a next round of splicing.
    Trvalý link: https://hdl.handle.net/11104/0342107

     
     
Počet záznamů: 1  

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