Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies

0570124 - ÚOCHB 2024 RIV US eng M - Část monografie knihy
Klán, P. - Slanina, Tomáš - Štacko, P.
Light-activatable H2S donors.
Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies. Hoboken: John Wiley & Sons, 2023 - (Pluth, M.), s. 347-372. Wiley series in drug discovery and development. ISBN 978-1-119-79987-0
Grant CEP: GA ČR(CZ) GJ19-20467Y; GA MŠMT(CZ) LTAIN19166
Institucionální podpora: RVO:61388963
Klíčová slova: hydrogen sulfide * light activation * H2S donor
Obor OECD: Organic chemistry
https://doi.org/10.1002/9781119799900.ch14

The chapter focuses on the release and delivery of hydrogen sulfide (H2S) from photoactivatable molecules using light as a biorthogonal trigger. We start with the introduction of photophysical and photochemical concepts related to their design. Standard methods of light delivery to human tissue and factors that limit the applicability of near-infrared irradiation wavelengths, allowing for deep tissue penetration, are subsequently reviewed. The most common methods of delivering light into the living organisms are briefly summarized and compared in the light of their clinical application. We show different mechanistic approaches to light-activated H2S release and provide a comprehensive survey of small organic molecules, organometallic complexes, supramolecular materials, and nanocomposites that can be used as H2S photodonors. The chapter concludes by highlighting the major challenges and obstacles to fuel future endeavors in the field of light-activated H2S donors.
Trvalý link: https://hdl.handle.net/11104/0341484