Telomeres expand sphere of influence: emerging molecular impact of telomeres in non-telomeric functions

0569311 - BFÚ 2024 RIV NL eng J - Článek v odborném periodiku
Vinayagamurthy, S. - Bagri, S. - Mergny, Jean-Louis - Chowdhury, S.
Telomeres expand sphere of influence: emerging molecular impact of telomeres in non-telomeric functions.
Trends in Genetics. Roč. 39, č. 1 (2023), s. 59-73. ISSN 0168-9525. E-ISSN 1362-4555
Grant CEP: GA MŠMT EF15_003/0000477
Institucionální podpora: RVO:68081707
Klíčová slova: G-QUADRUPLEX DNA * TERT PROMOTER MUTATIONS * MEDIATED GENE-EXPRESSION
Obor OECD: Genetics and heredity (medical genetics to be 3)
Impakt faktor: 11.4, rok: 2022
Způsob publikování: Open access
https://www.sciencedirect.com/science/article/pii/S0168952522002505?via%3Dihub

Although the impact of telomeres on physiology stands well established, a question remains: how do telomeres impact cellular functions at a molecular level? This is because current understanding limits the influence of telomeres to adjacent subtelomeric regions despite the wide-ranging impact of telomeres. Emerging work in two distinct aspects offers opportunities to bridge this gap. First, telomere-binding factors were found with non-telomeric functions. Second, locally induced DNA secondary structures called G-quadruplexes are notably abundant in telomeres, and gene regulatory regions genome wide. Many telomeric factors bind to G-quadruplexes for non-telomeric functions. Here we discuss a more general model of how telomeres impact the non-telomeric genome through factors that associate at telomeres and genome wide and influence cell-intrinsic functions, particularly aging, cancer, and pluripotency.
Trvalý link: https://hdl.handle.net/11104/0350446