Role of interferon-induced GTPases in leishmaniasis

0569188 - ÚMG 2023 RIV US eng J - Článek v odborném periodiku
Lipoldová, Marie - Sohrabi, Yahya
Role of interferon-induced GTPases in leishmaniasis.
PLoS Neglected Tropical Diseases. Roč. 16, č. 1 (2022), č. článku e0010093. ISSN 1935-2735. E-ISSN 1935-2735
Grant CEP: GA MZd NV19-05-00457
Institucionální podpora: RVO:68378050
Klíčová slova: guanylate-binding proteins * infection
Obor OECD: Infectious Diseases
Impakt faktor: 3.8, rok: 2022
Způsob publikování: Open access
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010093

Guanylate-binding proteins (GBPs) are components of cell-autonomous immunity against intracellular pathogens. They were shown to play an important role in response to multiple viral, bacterial, and protozoan pathogens, but before our research nothing was known about their role in leishmaniasis. In this invited comment we spotlight this novel mechanism of defense against Leishmania parasites that includes increase of expression of mRNA of GBPs after infection of different Leishmania species, involvement GBPs in direct killing of L. donovani in nonphagocytic cells, as well as their possible role in control of L. major in skin. We highlight the challenges and perspectives arising from this novel field of research.This invited comment-review summarizes the role of guanylate-binding proteins in leishmaniasis highlighting the challenges and perspectives arising from this novel field of research.
Trvalý link: https://hdl.handle.net/11104/0340533