Neurogenesis as a Tool for Spinal Cord Injury

0568846 - ÚEM 2023 RIV CH eng J - Článek v odborném periodiku
Havelíková, Kateřina - Smejkalová, Barbora - Jendelová, Pavla
Neurogenesis as a Tool for Spinal Cord Injury.
International Journal of Molecular Sciences. Roč. 23, č. 7 (2022), č. článku 3728. E-ISSN 1422-0067
Grant CEP: GA ČR(CZ) GA19-10365S; GA MŠMT(CZ) EF15_003/0000419
Institucionální podpora: RVO:68378041
Klíčová slova: neurogenesis * spinal cord injury * ependymal stem cells * astrocytes * reprogramming * spinal canal * physical factors * valproic acid * growth factors * neuroinflammation
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 5.6, rok: 2022
Způsob publikování: Open access
https://www.mdpi.com/1422-0067/23/7/3728

Spinal cord injury is a devastating medical condition with no effective treatment. One approach to SCI treatment may be provided by stem cells (SCs). Studies have mainly focused on the transplantation of exogenous SCs, but the induction of endogenous SCs has also been considered as an alternative. While the differentiation potential of neural stem cells in the brain neurogenic regions has been known for decades, there are ongoing debates regarding the multipotent differentiation potential of the ependymal cells of the central canal in the spinal cord (SCECs). Following spinal cord insult, SCECs start to proliferate and differentiate mostly into astrocytes and partly into oligodendrocytes, but not into neurons. However, there are several approaches concerning how to increase neurogenesis in the injured spinal cord, which are discussed in this review. The potential treatment approaches include drug administration, the reduction of neuroinflammation, neuromodulation with physical factors and in vivo reprogramming.
Trvalý link: https://hdl.handle.net/11104/0340110