The Role of miR-20 in Health and Disease of the Central Nervous System

0568840 - ÚEM 2023 RIV CH eng J - Článek v odborném periodiku
Arzhanov, Ivan - Šintáková, Kristýna - Romanyuk, Nataliya
The Role of miR-20 in Health and Disease of the Central Nervous System.
Cells. Roč. 11, č. 9 (2022), č. článku 1525. E-ISSN 2073-4409
Grant CEP: GA ČR(CZ) GA18-21942S; GA MZd(CZ) NU21-08-00286
Institucionální podpora: RVO:68378041
Klíčová slova: microRNA * miR-20a * central nervous system
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 6, rok: 2022
Způsob publikování: Open access
https://www.mdpi.com/2073-4409/11/9/1525

Current understanding of the mechanisms underlying central nervous system (CNS) injury is limited, and traditional therapeutic methods lack a molecular approach either to prevent acute phase or secondary damage, or to support restorative mechanisms in the nervous tissue. microRNAs (miRNAs) are endogenous, non-coding RNA molecules that have recently been discovered as fundamental and post-transcriptional regulators of gene expression. The capacity of microRNAs to regulate the cell state and function through post-transcriptionally silencing hundreds of genes are being acknowledged as an important factor in the pathophysiology of both acute and chronic CNS injuries. In this study, we have summarized the knowledge concerning the pathophysiology of several neurological disorders, and the role of most canonical miRNAs in their development. We have focused on the miR-20, the miR-17 similar to 92 family to which miR-20 belongs, and their function in the normal development and disease of the CNS.
Trvalý link: https://hdl.handle.net/11104/0340101