Telomerase as a possible key to bypass reproductive cost

0568472 - BC 2024 RIV US eng J - Článek v odborném periodiku
Čapková Frydrychová, Radmila
Telomerase as a possible key to bypass reproductive cost.
Molecular Ecology. Roč. 32, č. 9 (2023), s. 2134-2143. ISSN 0962-1083. E-ISSN 1365-294X
Grant ostatní: AV ČR(CZ) StrategieAV21/9
Program: StrategieAV
Institucionální podpora: RVO:60077344
Klíčová slova: ageing * cost of reproduction * reproduction strategy
Obor OECD: Reproductive biology (medical aspects to be 3)
Impakt faktor: 4.9, rok: 2022
Způsob publikování: Open access
https://onlinelibrary.wiley.com/doi/epdf/10.1111/mec.16870

Three widely accepted assumptions are based on telomere research in human cells: (i) telomere length is a determinant of replicative ageing, (ii) telomerase activity in somatic cells supports the proliferative capacity of the cells and thus contributes to their regenerative potential and is a determinant of organismal lifespan, and (iii) the lack of telomerase activity acts as a tumour suppression mechanism. However, from a broader view, the link between telomere biology and cellular and organismal ageing, as well as tumour development, remains of debate, as I demonstrate with numerous examples of invertebrate and vertebrate species. Consequently, I propose a novel hypothesis that telomere biology, via somatic telomerase activity, reflects ageing rate from the perspective of species reproduction strategy.
Trvalý link: https://hdl.handle.net/11104/0349843