Cubosomal lipid nanoassemblies with pH-sensitive shells created by biopolymer complexes: A synchrotron SAXS study

0568080 - FZÚ 2023 RIV US eng J - Článek v odborném periodiku
Mathews, P.D. - Mertins, O. - Angelov, Borislav - Angelova, A.
Cubosomal lipid nanoassemblies with pH-sensitive shells created by biopolymer complexes: A synchrotron SAXS study.
Journal of Colloid and Interface Science. Roč. 607, Feb (2022), s. 440-450. ISSN 0021-9797. E-ISSN 1095-7103
Grant CEP: GA MŠMT EF15_003/0000447; GA MŠMT EF16_019/0000789
Grant ostatní: OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447; OP VVV - ADONIS(XE) CZ.02.1.01/0.0/0.0/16_019/0000789
Institucionální podpora: RVO:68378271
Klíčová slova: self-assembled lipid/biopolymer complexes * cubic phase nanoparticles (cubosomes) * N-arginine-modified chitosan
Obor OECD: Biophysics
Impakt faktor: 9.9, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.jcis.2021.08.187

We report a strategy for sustainable development of pH-responsive cubic liquid crystalline nanoparticles (cubosomes), in which the structure-defining lyotropic nonlamellar lipid and the eventually encapsulated guest molecules can be protected by pH-sensitive polyelectrolyte shells with mucoadhesive properties. Bulk non-lamellar phases as well as pH-responsive polyelectrolyte-modified nanocarriers were formed by spontaneous assembly of the nonlamellar lipid monoolein and two biopolymers tailored in nanocomplexes with pH-dependent net charge.
Trvalý link: https://hdl.handle.net/11104/0339435