Self-assembled nanoscale materials for neuronal regeneration: a focus on BDNF Protein and nucleic acid biotherapeutic delivery

0567933 - FZÚ 2023 RIV CH eng J - Článek v odborném periodiku
Wu, Y. - Rakotoarisoa, M. - Angelov, Borislav - Deng, Y. - Angelova, A.
Self-assembled nanoscale materials for neuronal regeneration: a focus on BDNF Protein and nucleic acid biotherapeutic delivery.
Nanomaterials. Roč. 12, č. 13 (2022), č. článku 2267. E-ISSN 2079-4991
Grant CEP: GA MŠMT EF15_003/0000447; GA MŠMT EF16_019/0000789
Grant ostatní: OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447; OP VVV - ADONIS(XE) CZ.02.1.01/0.0/0.0/16_019/0000789
Institucionální podpora: RVO:68378271
Klíčová slova: neuroprotective assemblies * brain-derived neurotrophic factor (BDNF) * nanomedicine for growth factor delivery
Obor OECD: Fluids and plasma physics (including surface physics)
Impakt faktor: 5.3, rok: 2022
Způsob publikování: Open access

Enabling challenging applications of nanomedicine and precision medicine in the treatment of neurodegenerative disorders requires deeper investigations of nanocarrier-mediated biomolecular delivery for neuronal targeting and recovery. The successful use of macromolecular biotherapeutics (recombinant growth factors, antibodies, enzymes, synthetic peptides, cell-penetrating peptide–drug conjugates, and RNAi sequences) in clinical developments for neuronal regeneration should benefit from the recent strategies for enhancement of their bioavailability. We highlight the advances in the development of nanoscale materials for drug delivery in neurodegenerative disorders. The emphasis is placed on nanoformulations for the delivery of brain-derived neurotrophic factor (BDNF) using different types of lipidic nanocarriers (liposomes, liquid crystalline or solid lipid nanoparticles) and polymer-based scaffolds, nanofibers and hydrogels.
Trvalý link: https://hdl.handle.net/11104/0339215