Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids

0567779 - BC 2023 RIV GB eng J - Článek v odborném periodiku
Gahura, Ondřej - Chauhan, Prashant - Zíková, Alena
Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids.
Trends in Parasitology. Roč. 38, č. 12 (2022), s. 1053-1067. ISSN 1471-4922. E-ISSN 1471-5007
Grant CEP: GA ČR(CZ) GJ20-04150Y; GA MŠMT(CZ) EF16_019/0000759
Institucionální podpora: RVO:60077344
Klíčová slova: assembly factor * biogenesis * mitochondrial ribosomes * mitoribosomes * Trypanosoma
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 9.6, rok: 2022
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S1471492222001878?via%3Dihub

Translation in mitochondria is mediated by mitochondrial ribosomes, or mitoribosomes, complex ribonucleoprotein machines with dual genetic origin. Mitoribosomes in trypanosomatid parasites diverged markedly from their bacterial ancestors and other eukaryotic lineages in terms of protein composition, rRNA content, and overall architecture, yet their core functional elements remained conserved. Recent cryo-electron microscopy studies provided atomic models of trypanosomatid large and small mitoribosomal subunits and their precursors, making these parasites the organisms with the best-understood biogenesis of mitoribosomes. The structures revealed molecular mechanisms and players involved in the assembly of mitoribosomes not only in the parasites, but also in eukaryotes in general.
Trvalý link: https://hdl.handle.net/11104/0339044