MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker

0567756 - ÚEM 2023 RIV NL eng J - Článek v odborném periodiku
Červená, Klára - Vodenková, Soňa - Vymetálková, Veronika
MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker.
Gene. Roč. 843, aug (2022), č. článku 146791. ISSN 0378-1119. E-ISSN 1879-0038
Grant CEP: GA MZd(CZ) NU22J-03-00033; GA ČR(CZ) GA22-05942S
Institucionální podpora: RVO:68378041
Klíčová slova: lncRNA * ceRNA * MALAT1 * biomarker * colorectal cancer
Obor OECD: Cell biology
Impakt faktor: 3.5, rok: 2022
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/abs/pii/S0378111922006102?via%3Dihub

Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1), originally described as a prognostic biomarker remarkably linked with metastasis potential in lung cancer, has been identified as contributing to many diseases, including colorectal cancer (CRC). This long non-coding RNA (lncRNA) has come to the forefront of lncRNA research for its implications in cancer-related processes, such as cell proliferation and migration. In general, lncRNAs are recognized as enhancers, scaffolds, or decoys for a variety of oncogenes and tumor sup-pressors, although our understanding of lncRNA functions and mechanisms of action is still limited. Nowadays, cancer research is attracted to lncRNAs' ability to improve the early diagnosis of cancer, determine patients' prognosis, or predict therapy outcomes. In this review, we aimed to evaluate recent publications trying to un-cover the cellular mechanisms of MALAT1-mediated regulation, and its potential exploitation in the management of CRC. The conclusions of this review provide robust support for the essential role of MALAT1 in CRC devel-opment and future personalized therapy.
Trvalý link: https://hdl.handle.net/11104/0339004