0567211 - ÚMG 2023 RIV US eng J - Článek v odborném periodiku
Jackman, Janet K. - Stockwell, A. - Choy, David F. - Xie, Markus M. - Lu, P. - Jia, G. - Li, H. - Abbas, Alexander R. - Bronson, Paola G. - Lin, W. - Chiu, Cecilia P. C. - Maun, Henry R. - Roose-Girma, M. - Tam, L. - Zhang, J. - Modrusan, Z. - Graham, Robert R. - Behrens, Timothy W. - White, Steven R. - Naureckas, T. - Ober, C. - Ferreira, M. - Sedláček, Radislav - Wu, J. - Lee, Wyne P. - Lazarus, Robert A. - Koerber, James T. - Arron, J. R. - Yaspan, B. L. - Yi, T.
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma.
Journal of Allergy and Clinical Immunology. Roč. 150, č. 4 (2022), s. 972-978.e7. ISSN 0091-6749. E-ISSN 1097-6825
Institucionální podpora: RVO:68378050
Klíčová slova: T2-low asthma * genome-wide association * klk5 * spink5
Obor OECD: Immunology
Impakt faktor: 14.2, rok: 2022
Způsob publikování: Open access
Web výsledku:
https://www.sciencedirect.com/science/article/pii/S0091674922005553?via%3Dihub
DOI: https://doi.org/10.1016/j.jaci.2022.03.033

Background: Clinical studies of type 2 (T2) cytokine-related neutralizing antibodies in asthma have identified a substantial subset of patients with low levels of T2 inflammation who do not benefit from T2 cytokine neutralizing antibody treatment. Non-T2 mechanisms are poorly understood in asthma but represent a redefined unmet medical need.

Trvalý link: https://hdl.handle.net/11104/0338493