Interaction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and CYP3A4) enzymes and organic anion transporting polypeptide (OATP1B1 and OATP2B1) transporters

0567079 - MBÚ 2024 RIV NL eng J - Článek v odborném periodiku
Kaci, H. - Bodnárová, S. - Fliszar-Nyul, E. - Lemli, B. - Pelantová, Helena - Valentová, Kateřina - Bakos, E. - Ozvegy-Laczka, C. - Poór, M.
Interaction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and CYP3A4) enzymes and organic anion transporting polypeptide (OATP1B1 and OATP2B1) transporters.
Biomedicine & Pharmacotherapy. Roč. 157, January 23 (2023), č. článku 114078. ISSN 0753-3322. E-ISSN 1950-6007
Grant CEP: GA ČR GA21-00551S
Institucionální podpora: RVO:61388971
Klíčová slova: Luteolin * Naringenin * Sulfate * glucuronide metabolites * Human serum albumin * Cytochrome P450 enzymes * OATP transporters
Obor OECD: Pharmacology and pharmacy
Impakt faktor: 7.5, rok: 2022
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0753332222014676?via%3Dihub

Luteolin and naringenin are flavonoids found in various foods/beverages and present in certain dietary sup-plements. After a high intake of these flavonoids, their sulfate and glucuronide conjugates reach micromolar concentrations in the bloodstream. Some pharmacokinetic interactions of luteolin and naringenin have been investigated in previous studies, however, only limited data are available in regard to their metabolites. In this study, we aimed to investigate the interactions of the sulfate and glucuronic acid conjugates of luteolin and naringenin with human serum albumin, cytochrome P450 (CYP2C9, 2C19, and 3A4) enzymes, and organic anion transporting polypeptide (OATP1B1 and OATP2B1) transporters. Our main findings are as follows: (1) Sulfate conjugates formed more stable complexes with albumin than the parent flavonoids. (2) Luteolin and naringenin conjugates showed no or only weak inhibitory action on the CYP enzymes examined. (3) Certain conjugates of luteolin and naringenin are potent inhibitors of OATP1B1 and/or OATP2B1 enzymes. (4) Conjugated metabolites of luteolin and naringenin may play an important role in the pharmacokinetic interactions of these flavonoids.
Trvalý link: https://hdl.handle.net/11104/0342645