Počet záznamů: 1
Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases
- 1.0566963 - ÚOCHB 2023 RIV eng P - Patentový dokument
Slusher, B. - Rojas, C. - Thomas, A. G. - Nencka, Radim - Šála, Michal - Hřebabecký, Hubert - Haughey, N.
Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases.
2022. Vlastník: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR v. v. i. Datum udělení patentu: 30.08.2022. Číslo patentu: US11427590
Grant CEP: GA MŠMT(CZ) EF16_019/0000729
Institucionální podpora: RVO:61388963
Klíčová slova: nSMase2 * Alzheimer’s disease * brain penetration
Obor OECD: Medicinal chemistry
https://worldwide.espacenet.com/patent/search/family/062791143/publication/US11427590B2?q=pn%3DUS11427590B2
Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer, are provided.
Trvalý link: https://hdl.handle.net/11104/0338223
Počet záznamů: 1