Skin microbiota signature distinguishes IBD patients and reflects skin adverse events during anti-TNF therapy

0566813 - MBÚ 2023 RIV CH eng J - Článek v odborném periodiku
Reiss, Zuzana - Rob, F. - Kolář, M. - Schierová, Dagmar - Kreisinger, J. - Jacková, Zuzana - Roubalová, Radka - Coufal, Štěpán - Mihula, Martin - Thon, Tomáš - Bajer, Lukáš - Nováková, M. - Vašátko, M. - Kostovčíková, Klára - Galanová, Natálie - Lukáš, M. - Kverka, Miloslav - Třešňák Hercogová, J. - Tlaskalová-Hogenová, Helena - Jirásková Zákostelská, Zuzana
Skin microbiota signature distinguishes IBD patients and reflects skin adverse events during anti-TNF therapy.
Frontiers in Cellular and Infection Microbiology. Roč. 13, January 10 (2023), č. článku 1064537. ISSN 2235-2988. E-ISSN 2235-2988
Grant CEP: GA MZd(CZ) NV18-09-00493; GA MZd(CZ) NU22J-05-00056; GA ČR(CZ) GA20-03997S
Institucionální podpora: RVO:61388971
Klíčová slova: Skin microbiota * IBD * 16S RNA sequencing * Serum biomarker * TNF-alpha antagonist * Skin adverse events
Obor OECD: Microbiology
Impakt faktor: 5.7, rok: 2022
Způsob publikování: Open access
https://www.frontiersin.org/articles/10.3389/fcimb.2022.1064537/full

Crohn’s disease (CD) and ulcerative colitis (UC) are two forms of inflammatory bowel disease (IBD), where the role of gut but not skin dysbiosis is well recognized. Inhibitors of TNF have been successful in IBD treatment, but up to a quarter of patients suffer from unpredictable skin adverse events (SkAE). For this purpose, we analyzed temporal dynamics of skin microbiota and serum
markers of inflammation and epithelial barrier integrity during anti-TNF therapy and SkAE manifestation in IBD patients. We observed that the skin microbiota signature of IBD patients differs markedly from healthy subjects. In particular, the skin microbiota of CD patients differs significantly from that of UC patients and healthy subjects, mainly in the retroauricular crease. In addition, we showed that anti-TNF-related SkAE are associated with specific shifts in skin microbiota profile and with a decrease in serum levels of L-FABP and I-FABP in
IBD patients. For the first time, we showed that shifts in microbial composition in IBD patients are not limited to the gut and that skin microbiota and serum markers of the epithelium barrier may be suitable markers of SkAE during anti-TNF therapy.

Trvalý link: https://hdl.handle.net/11104/0338102