Laterality in functional and metabolic state of the bulbectomised rat brain detected by ASL and 1H MRS: A pilot study

0565353 - ÚPT 2024 RIV GB eng J - Článek v odborném periodiku
Pavlova, Iveta - Dražanová, Eva - Krátká, Lucie - Amchová, P. - Macíček, Ondřej - Starčuková, Jana - Starčuk jr., Zenon - Rudá-Kučerová, J.
Laterality in functional and metabolic state of the bulbectomised rat brain detected by ASL and 1H MRS: A pilot study.
World Journal of Biological Psychiatry. Roč. 24, č. 5 (2023), s. 414-428. ISSN 1562-2975. E-ISSN 1814-1412
Grant CEP: GA MŠMT(CZ) EF18_046/0016045
Institucionální podpora: RVO:68081731
Klíčová slova: Arterial spin labelling * depression * magnetic resonance spectroscopy * olfactory bulbectomy * rats
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 3.1, rok: 2022
Způsob publikování: Omezený přístup
https://www.tandfonline.com/doi/full/10.1080/15622975.2022.2124450

Objectives Pilot study validating the animal model of depression the bilateral olfactory bulbectomy in rats by two nuclear magnetic resonance methods, indirectly detecting the metabolic state of the brain. Furthermore, the study focussed on potential differences in brain laterality. Methods Arterial spin labelling assessed cerebral brain flow in prefrontal, sensorimotor, and piriform cortices, nucleus accumbens, hippocampus, thalamus, circle of Willis, and whole brain. Proton magnetic resonance spectroscopy provided information about relative metabolite concentrations in the cortex and hippocampus. Results Arterial spin labelling found no differences in cerebral perfusion in the group comparison but revealed lateralisation in the thalamus of the control group and the sensorimotor cortex of the bulbectomized rats. Lower Cho/tCr and Cho/NAA levels were found in the right hippocampus in bulbectomized rats. The differences in lateralisation were shown in the hippocampus: mI/tCr in the control group, Cho/NAA, NAA/tCr, Tau/tCr in the model group, and in the cortex: NAA/tCr, mI/tCr in the control group. Conclusion Olfactory bulbectomy affects the neuronal and biochemical profile of the rat brain laterally and, as a model of depression, was validated by two nuclear magnetic resonance methods.
Trvalý link: https://hdl.handle.net/11104/0336907