Microwave irradiation-assisted reversible addition-fragmentation chain transfer polymerization-induced self-assembly of pH-responsive diblock copolymer nanoparticles

0564924 - ÚMCH 2023 RIV US eng J - Článek v odborném periodiku
Lukáš Petrova, Svetlana - Sincari, Vladimir - Konefal, Rafal - Pavlova, Ewa - Hrubý, Martin - Pokorný, Václav - Jäger, Eliezer
Microwave irradiation-assisted reversible addition-fragmentation chain transfer polymerization-induced self-assembly of pH-responsive diblock copolymer nanoparticles.
ACS Omega. Roč. 7, č. 47 (2022), s. 42711-42722. ISSN 2470-1343. E-ISSN 2470-1343
Grant CEP: GA ČR(CZ) GJ20-15077Y; GA ČR(CZ) GA21-01090S; GA MŠMT(CZ) LM2018133
Institucionální podpora: RVO:61389013
Klíčová slova: polymerization-induced self-assembly * block copolymers * nano-objects
Obor OECD: Polymer science
Impakt faktor: 4.1, rok: 2022
Způsob publikování: Open access
https://pubs.acs.org/doi/10.1021/acsomega.2c04036

Herein, we present a versatile platform for the synthesis of pH-responsive poly([N-(2-hydroxypropyl)]methacrylamide)-b-poly[2-(diisopropylamino)ethyl methacrylate] diblock copolymer (PHPMA-b-PDPA) nanoparticles (NPs) obtained via microwave-assisted reversible addition–fragmentation chain transfer polymerization-induced self-assembly (MWI-PISA). The N-(2-hydroxypropyl) methacrylamide (HPMA) monomer was first polymerized to obtain a macrochain transfer agent with polymerization degrees (DPs) of 23 and 51. Subsequently, using mCTA and 2-(diisopropylamino)ethyl methacrylate (DPA) as monomers, we successfully conducted MWI-PISA emulsion polymerization in aqueous solution with a solid content of 10 wt %. The NPs were obtained with high monomer conversion and polymerization rates. The resulting diblock copolymer NPs were analyzed by dynamic light scattering (DLS) and cryogenic-transmission electron microscopy (cryo-TEM). cryo-TEM studies reveal the presence of only NPs with spherical morphology such as micelles and polymer vesicles known as polymersomes. Under the selected conditions, we were able to fine-tune the morphology from micelles to polymersomes, which may attract considerable attention in the drug-delivery field. The capability for drug encapsulation using the obtained in situ pH-responsive NPs, the polymersomes based on PHPMA23-b-PDPA100, and the micelles based on PHPMA51-b-PDPA100 was demonstrated using the hydrophobic agent and fluorescent dye as Nile red (NR). In addition, the NP disassembly in slightly acidic environments enables fast NR release.
Trvalý link: https://hdl.handle.net/11104/0337464