Mitochondrial adaptations throughout the Trypanosoma brucei life cycle

0564728 - BC 2023 RIV US eng J - Článek v odborném periodiku
Zíková, Alena
Mitochondrial adaptations throughout the Trypanosoma brucei life cycle.
Journal of Eukaryotic Microbiology. Roč. 69, č. 6 (2022), č. článku e12911. ISSN 1066-5234. E-ISSN 1550-7408
Grant CEP: GA ČR(CZ) GA20-14409S; GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GA22-34480S
Institucionální podpora: RVO:60077344
Klíčová slova: differentiation * metabolism * mitochondria * signaling * Trypanosoma
Obor OECD: Cell biology
Impakt faktor: 2.2, rok: 2022
Způsob publikování: Omezený přístup
https://onlinelibrary.wiley.com/doi/10.1111/jeu.12911

The unicellular parasite Trypanosoma brucei has a digenetic life cycle that alternates between a mammalian host and an insect vector. During programmed development, this extracellular parasite encounters strikingly different environments that determine its energy metabolism. Functioning as a bioenergetic, biosynthetic, and signaling center, the single mitochondrion of T. brucei is drastically remodeled to support the dynamic cellular demands of the parasite. This manuscript will provide an up-to-date overview of how the distinct T. brucei developmental stages differ in their mitochondrial metabolic and bioenergetic pathways, with a focus on the electron transport chain, proline oxidation, TCA cycle, acetate production, and ATP generation. Although mitochondrial metabolic rewiring has always been simply viewed as a consequence of the differentiation process, the possibility that certain mitochondrial activities reinforce parasite differentiation will be explored.
Trvalý link: https://hdl.handle.net/11104/0340561