Phosphonium carbosilane amphiphilic dendrons for self-assembly of drug nanocarriers.

0564634 - ÚCHP 2023 IT eng A - Abstrakt
Edr, Antonín - Apartsin, E.K. - Strašák, Tomáš
Phosphonium carbosilane amphiphilic dendrons for self-assembly of drug nanocarriers.
Book of Abstracts. 2022.
[International Conference on Multifunctional, Hybrid and Nanomaterials /7./. 19.10.2022-22.10.2022, Genoa]
GRANT EU: European Commission(XE) CA17140 - COST Action
Institucionální podpora: RVO:67985858
Klíčová slova: phosphonium * amphiphilic dendrons * drug nanocarriers
Obor OECD: Organic chemistry

Herein, we report a synthesis and basic physico-chemical properties of a new series of amphiphilic dendrons. The series carries triphenylphosphonium groups on its branched part as it was found that phosphonium groups show lower cytotoxicity in comparison with, e.g., commonly used ammonium
groups.3 Moreover, phosphonium groups generally facilitate internalization of the nanoparticle 4 and can mediate a successful transfection of an RNA.
5 As a lipophilic part, the series carries twelve- and eighteen carbon alkyl chains
Trvalý link: https://hdl.handle.net/11104/0336286