Size-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis

0564362 - ÚMCH 2024 RIV NL eng J - Článek v odborném periodiku
Libánská, Alena - Randárová, Eva - Skoroplyas, Svitlana - Bartoš, M. - Luňáčková, J. - Lager, F. - Renault, G. - Scherman, D. - Etrych, Tomáš
Size-switchable polymer-based nanomedicines in the advanced therapy of rheumatoid arthritis.
Journal of Controlled Release. Roč. 353, January (2023), s. 30-41. ISSN 0168-3659. E-ISSN 1873-4995
Grant CEP: GA MZd(CZ) NU20-08-00255; GA ČR(CZ) GJ19-00956Y
Institucionální podpora: RVO:61389013 ; RVO:68081707
Klíčová slova: polymer conjugate * drug delivery * inflammation
Obor OECD: Polymer science; Biophysics (BFU-R)
Impakt faktor: 10.8, rok: 2022
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0168365922007726?via%3Dihub

Chronic inflammatory diseases such as rheumatoid arthritis represent a substantial socio-economic impact and have a high prevalence in the modern world. Nano-sized polymer therapeutics have shown suitable characteristics for becoming the next generation of anti-inflammatory nanomedicines. Here, we present biocompatible and stimuli-sensitive N-(2-hydroxypropyl)methacrylamide based polymer conjugates with the anti-inflammatory drug dexamethasone (DEX), which has been tailored for prolonged blood circulation, enhanced inflammatory site accumulation, site-specific drug release and subsequent elimination of the carrier via urine excretion. The hydrodynamic size of novel polymer-DEX nanomedicine was adjusted to prolong its blood circulation whilst maintaining the renal excretability of the polymer carrier after drug release in inflamed tissue. The therapeutic efficacy of the studied polymer nanomedicines was evaluated in a model of dissipated chronic arthritis, i.e. collagen II-induced arthritis, in mice. The pH-sensitive drug attachment enabled enhanced blood circulation with minimal systemic drug release, as well as rapid drug activation in affected joints. Importantly, unlike free DEX, the polymer nanomedicines were able to diminish joint inflammation and arthritis-induced bone damage - even at a reduced dosing regimen - as evaluated by micro computed tomography (micro-CT).
Trvalý link: https://hdl.handle.net/11104/0336547