Association of late life depression, (Non-) modifiable risk and protective factors with dementia and Alzheimer's disease: Literature review on current evidences, preventive interventions and possible future trends in prevention and treatment of dementia

0563604 - FZÚ 2023 RIV CH eng J - Článek v odborném periodiku
Kuo, C.Y. - Stachiv, Ivo - Nikolai, T.
Association of late life depression, (Non-) modifiable risk and protective factors with dementia and Alzheimer's disease: Literature review on current evidences, preventive interventions and possible future trends in prevention and treatment of dementia.
International Journal of Environmental Research and Public Health. Roč. 17, č. 20 (2020), č. článku 7475. ISSN 1661-7827. E-ISSN 1660-4601
Grant CEP: GA MŠMT(CZ) EF16_019/0000760
Grant ostatní: OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institucionální podpora: RVO:68378271
Klíčová slova: dementia * Alzheimer´s disease * late life depression * apolipoprotein E * testosterone * obesity * social engagement * substance abuse
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 3.390, rok: 2020
Způsob publikování: Open access

The number of people living with dementia and Alzheimer’s disease is growing rapidly, making dementia one of the biggest challenges for this century. Many studies have indicated that depression plays an important role in development of dementia, including Alzheimer’s disease, depression, especially, during the late life may either increase the risk of dementia or even being its prodromal stage. Despite a notably large number of carried observational studies and/or clinical trials, the association between the late life depression and dementia remains, due to the complexity of their relationship, still unclear. Moreover, during past two decades multiple other (non-)modifiable risk and possibly protective factors such as the hypertension, social engagement, obesity, level of education or physical (in)activity have been identified and their relationship with the risk for development of dementia and Alzheimer’s disease has been extensively studied.

Trvalý link: https://hdl.handle.net/11104/0335512