Structuring and de-structuring of nanovectors from algal lipids. Part 1: physico-chemical characterization

0563072 - ÚMCH 2023 RIV NL eng J - Článek v odborném periodiku
Clemente, I. - D´Aria, F. - Giancola, C. - Bonechi, C. - Šlouf, Miroslav - Pavlova, Ewa - Rossi, C. - Ristori, S.
Structuring and de-structuring of nanovectors from algal lipids. Part 1: physico-chemical characterization.
Colloids and Surfaces B-Biointerfaces. Roč. 220, December (2022), č. článku 112939. ISSN 0927-7765. E-ISSN 1873-4367
Institucionální podpora: RVO:61389013
Klíčová slova: nanocarriers * algal lipids * structure
Obor OECD: Polymer science
Impakt faktor: 5.8, rok: 2022
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0927776522006233?via%3Dihub

Lipid nanocarriers are among the most employed systems for drug delivery purposes in several research and industrial sectors, since their favorable properties ensure broad applicability. The design and characterization of these nanosystems are of paramount importance to obtain controlled outcome, since the supramolecular structure and molecular interactions deeply impact the functionality of the resulting aggregates. The choice of the most appropriate formulation for the target of interest relies on in-depth physico-chemical characterization in order to optimize stability, loading rates and sustained release. Several supramolecular architectures suited for carrier development can be obtained from lipid building blocks, by varying lipid composition and packing parameter. In particular, cubosome and liposome aggregates are often used as drug vectors thanks to their high cargo capability and biocompatibility. Moreover, the possibility to employ lipids from natural sources i.e. biomasses to prepare nanosystems makes them especially attractive. In this work, two aggregate types were characterized and compared as drug vectors for poorly water-soluble antioxidants, particularly curcumin and two adjuvants (i.e. tocopherol and piperine). The nanovectors were obtained by extracting lipids from algal biomasses with different lipid composition, and characterized by advanced structural (DLS, SAXS, Cryo-TEM) techniques, spectroscopy (NMR) and calorimetry (ITC). Finally, the structural stability of both aggregate types was evaluated.
Trvalý link: https://hdl.handle.net/11104/0335452